Course Syllabus

Course Information：

Year-Semester Course Number Course Name Phase Credits Hours Required/Elective Instructor Class Student NO. Withdraw Note

Fall Semester
Year 2025 350850 Biomedical nano/micro-engineering 1 3.0 3 ★ Yen Yi-Kuang GME 23 0 甲組◎；甲、丙組選修,限25人

Year-Semester	Course Number	Course Name	Phase	Credits	Hours	Required/Elective	Instructor	Class	Student NO.	Withdraw	Note
Fall Semester Year 2025	350850	Biomedical nano/micro-engineering	1	3.0	3	★	Yen Yi-Kuang	GME	23	0	甲組◎；甲、丙組選修,限25人

Course Plan：

Instructor Yen Yi-Kuang　Office Hours

Email yknewman@gmail.com

Last Updated 2025-11-17 15:52:28

Course Objective 奈微米工程於生物醫學之應用日趨重要，量測與操作工具的開發與實際的生醫應用對象的大小尺寸具有密切的相關性，對於生物系統的充份瞭解是工程表現的重要過程之一。在此課程中將配合本校實驗室目前之相關研究設備進行原理講解與應用討論，包括之項目將由分子、細胞到組織之感測、分析與操縱。選修學生須依下列重點：奈微米生醫感測系統、奈米生醫材料、奈米生醫光電以及實驗室晶片等領域選擇期中期末報告之題目與計畫內容，主要要求在尋求創新思考方向，以求在原理或應用上的突破，積極推動跨領域與技術先進之整合性研究。 The application of nano-micron engineering in biomedicine is becoming more and more important. The development of measurement and operation tools is closely related to the size of actual biomedical application objects. A full understanding of biological systems is one of the important processes of engineering performance. In this course, the principle explanation and application discussion will be carried out with the current research equipment in our laboratory, including the sensing, analysis and manipulation of molecules. Elective students should choose the topics and project content of the mid-term report in the fields of nano-micron biomedical sensing system, nano-biomedical materials, nano-biomedical optoelectronics, and laboratory chips. The main requirement is to seek innovative thinking , In order to seek breakthroughs in principles or applications, and actively promote integrated research across fields and advanced technologies.

Course Schedule Week Topics 1 Introduction of course, Grouping 2 CMOS MEMS Overview, Introduction of CIC for Chip design 3 Introduction of BioMEMS and Chip design 4 Introduction of nano-bio-chip and Chip design 5 Review in Micro & Nano Technologies and Chip design 6 Project proposal presentation 7 cantilever biosensor I 8 cantilever biosensor II 9 Affinity principle and SPR and ELISA 10 Paper based sensors 11 Biosensor telecare overview 12 Bio Thin film coating technology 13 TIRFM 14 MOCSER 15 FET and electrochemical biosensors 16 Final Project Presentation and demo 17 Final Project Presentation and demo 18 Final thesis report deadline Lab Project List: Project 1 Soft lithography (fabrication) Mixing (Testing) PDMS & Microscale Mixing, Project 2 3D Printing (fabrication) Hydrodynamic Focusing or chemical reaction (Testing) 3D Printing based microfluidics Project 3 Paper based sensor (fabrication) Chemical or biological (testing) Paper based sensors Project 4 Microcantilever sensor (characterization, testing) Microcantilever Chemical Sensor

Evaluation and grading policy 1. Grading: Lab project: 55%  Team work 20%  Project proposal presentation 15%  Project final presentation 20% 2. Q&A in class: 15% 3. Final thesis report : 30%

Materials All right reserved. Do not reproduce without permission.

Foreign-language textbooks:Yes
Class slide handout. BioMEMS, Technologies and Applications By Wanjun Wang (ME, LSU), and Steven A. Soper (Chem. LSU)

The access to curricular consultation Students can contact me via line, physical discussion in the laboratory or online remote meeting discussion. The class will use Google Classroom platform for teaching.

Expanding teaching and resources

The course corresponds to the SDGs SDG3：良好健康和福祉（Good Health and Well-being）
SDG6：潔淨水與衛生（Clean Water and Sanitation）
SDG17：夥伴關係（Partnerships for the Goals）

Does the course incorporate AI ● 鼓勵學生使用生成式AI工具（Encourage students to use generative AI tools）

Note
講堂課教室：綜科802
實作課教室：會改至綜科709-1。

Instructor	Yen Yi-Kuang　Office Hours
Email	yknewman@gmail.com
Last Updated	2025-11-17 15:52:28
Course Objective	奈微米工程於生物醫學之應用日趨重要，量測與操作工具的開發與實際的生醫應用對象的大小尺寸具有密切的相關性，對於生物系統的充份瞭解是工程表現的重要過程之一。在此課程中將配合本校實驗室目前之相關研究設備進行原理講解與應用討論，包括之項目將由分子、細胞到組織之感測、分析與操縱。選修學生須依下列重點：奈微米生醫感測系統、奈米生醫材料、奈米生醫光電以及實驗室晶片等領域選擇期中期末報告之題目與計畫內容，主要要求在尋求創新思考方向，以求在原理或應用上的突破，積極推動跨領域與技術先進之整合性研究。 The application of nano-micron engineering in biomedicine is becoming more and more important. The development of measurement and operation tools is closely related to the size of actual biomedical application objects. A full understanding of biological systems is one of the important processes of engineering performance. In this course, the principle explanation and application discussion will be carried out with the current research equipment in our laboratory, including the sensing, analysis and manipulation of molecules. Elective students should choose the topics and project content of the mid-term report in the fields of nano-micron biomedical sensing system, nano-biomedical materials, nano-biomedical optoelectronics, and laboratory chips. The main requirement is to seek innovative thinking , In order to seek breakthroughs in principles or applications, and actively promote integrated research across fields and advanced technologies.
Course Schedule	Week Topics 1 Introduction of course, Grouping 2 CMOS MEMS Overview, Introduction of CIC for Chip design 3 Introduction of BioMEMS and Chip design 4 Introduction of nano-bio-chip and Chip design 5 Review in Micro & Nano Technologies and Chip design 6 Project proposal presentation 7 cantilever biosensor I 8 cantilever biosensor II 9 Affinity principle and SPR and ELISA 10 Paper based sensors 11 Biosensor telecare overview 12 Bio Thin film coating technology 13 TIRFM 14 MOCSER 15 FET and electrochemical biosensors 16 Final Project Presentation and demo 17 Final Project Presentation and demo 18 Final thesis report deadline Lab Project List: Project 1 Soft lithography (fabrication) Mixing (Testing) PDMS & Microscale Mixing, Project 2 3D Printing (fabrication) Hydrodynamic Focusing or chemical reaction (Testing) 3D Printing based microfluidics Project 3 Paper based sensor (fabrication) Chemical or biological (testing) Paper based sensors Project 4 Microcantilever sensor (characterization, testing) Microcantilever Chemical Sensor
Evaluation and grading policy	1. Grading: Lab project: 55%  Team work 20%  Project proposal presentation 15%  Project final presentation 20% 2. Q&A in class: 15% 3. Final thesis report : 30%
Materials	All right reserved. Do not reproduce without permission. Foreign-language textbooks:Yes Class slide handout. BioMEMS, Technologies and Applications By Wanjun Wang (ME, LSU), and Steven A. Soper (Chem. LSU)
The access to curricular consultation	Students can contact me via line, physical discussion in the laboratory or online remote meeting discussion. The class will use Google Classroom platform for teaching.
Expanding teaching and resources
The course corresponds to the SDGs	SDG3：良好健康和福祉（Good Health and Well-being） SDG6：潔淨水與衛生（Clean Water and Sanitation） SDG17：夥伴關係（Partnerships for the Goals）
Does the course incorporate AI	● 鼓勵學生使用生成式AI工具（Encourage students to use generative AI tools）
Note	講堂課教室：綜科802 實作課教室：會改至綜科709-1。